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The 21D Challenge is a comprehensive 3-phase detox system that cleanses your colon, purifies your liver, and restores your digestive balance — all in just 21 days.
A complete 3-phase detox system with everything you need for 21 days
Follow the 3-phase protocol: 5 days colon cleanse with Colon-D tea + ProEnzi+, 2 days liver detox with Liver-D, then 14 days of guided nutrition for lasting results.
See what our customers are saying about the 21D Challenge
"I was skeptical at first, but by day 7 I already felt lighter and more energized. The liver detox phase was intense but so worth it. Best investment in my health!"
Dallas, TX
Verified Buyer
"I've tried many detox programs before but nothing compares to the 21D Challenge. The step-by-step instructions made it so easy to follow. I lost 8 pounds and feel amazing!"
Phoenix, AZ
Verified Buyer
"My digestion has completely transformed. No more bloating, no more heartburn. I recommend this kit to everyone in my family. We're all doing the challenge together!"
Chicago, IL
Verified BuyerNot all detox programs are created equal. Here's how the 21D Challenge compares to typical cleanses and detox teas.
21D ChallengeThe 21D Challenge combines Colon-D's natural herbal tea (persimmon leaves, malva, holy thistle, marshmallow, blessed thistle) with ProEnzi+'s powerful blend of probiotics and digestive enzymes (Lactobacillus acidophilus, bromelain, papain) to cleanse and restore your digestive system from day one.
Phase 2 targets your liver with Liver-D's dual-action formula: Liver Support (extra virgin olive oil, Vitamin E) and Liver Mix (ascorbic acid, magnesium sulfate, yucca root, artichoke extract, milk thistle, ginger root, and turmeric with 95% curcuminoids).
Your liver filters blood, produces bile, metabolizes nutrients, and neutralizes toxins around the clock. When it's overloaded with processed foods, alcohol, medications, and environmental toxins, its efficiency drops — leading to fatigue, bloating, skin problems, and weakened immunity.
The 21D Challenge works in phases: first clearing your colon to improve nutrient absorption, then deeply purifying your liver to restore its natural function, and finally nourishing your body with a guided nutrition plan. This systematic approach ensures lasting results, not just a quick fix.
Follow these three phases for a complete body reset
Dedicated professionals combining science, innovation, and passion to create revolutionary health solutions.
Graduate of BUAP (2017) with 8+ years specializing in nutraceutical R&D. Creator of 150+ innovative formulas.
BUAP graduate with 12+ years in pharmaceutical and nutraceutical industries. Expert in GMP implementation.
BUAP graduate recognized for research excellence at international conferences. Selected by CONACYT (2019).
Doctor of Naturopathy with 10+ years in health and wellness. Pioneering force behind iEvolution's Liver Detox.
Licensed in Nutrition with postgraduate in Clinical Nutrition and Ketogenic Diet certification.
Clinical Biochemical Nutrition specialist from Tec de Monterrey. Advanced studies from Yale and Anáhuac.
Everything you need to know about the 21D Challenge
The 21D Challenge is a comprehensive 21-day detox program that includes three products working together in a 3-phase system:
The program follows a structured protocol: 5 days of colon cleansing, 2 days of liver detox, and 14 days of guided nutrition.
Phase 1 (Days 1–5): Colon-D tea cleanses your colon while ProEnzi+ provides probiotics and enzymes to support digestion and restore intestinal flora.
Phase 2 (Days 6–7): Liver-D performs a deep liver purification. Liver Support prepares the liver with olive oil and Vitamin E, while Liver Mix delivers a potent blend of curcumin, milk thistle, artichoke extract, and magnesium for a thorough cleanse.
Phase 3 (Days 8–21): A guided nutrition plan helps you maintain results and establish healthy eating habits.
Colon-D: Persimmon leaves, malva leaves, holy thistle, marshmallow leaves, blessed thistle, and fennel.
Liver Support: Extra virgin olive oil and Vitamin E.
Liver Mix: Vitamin C (ascorbic acid), magnesium sulfate, yucca root, artichoke 4:1 extract, dandelion 4:1 extract, milk thistle extract, ginger root, and turmeric root extract (95% curcuminoids).
ProEnzi+: Lactobacillus acidophilus, L. casei, L. plantarum, bromelain, papain, fungal lipase, fungal lactase, alpha galactosidase, and aspergillus fungal protease.
Yes! All products in the kit are made with 100% natural ingredients. However, we recommend consulting with your doctor before starting if you are pregnant, nursing, taking medication, or have any medical conditions.
The liver detox phase (Days 6–7) can cause temporary effects like mild nausea or increased bowel movements — this is normal and a sign the detox is working. Stay well hydrated throughout the process.
Results vary by individual, but most people report:
For best results, follow the complete 21-day protocol including the nutrition plan in Phase 3.
During Phase 1 (Days 1–5), eat normally but try to reduce processed foods and heavy carbohydrates.
During Phase 2 (Days 6–7), follow the specific meal guidelines: light breakfast on Day 6, chicken broth for lunch, no dinner. Day 7: skip breakfast, light meals only.
During Phase 3 (Days 8–21), follow the guided nutrition plan provided with your kit for optimal results.
We recommend doing the full 21D Challenge every 3–4 months for maintenance. Between challenges, you can continue taking ProEnzi+ daily for ongoing digestive support and use Colon-D tea occasionally.
Many customers also pair the 21D Challenge with other iEvolution products like Daily Liver Plus for daily liver maintenance and Royal Coffee Latte for energy.
The 7D Challenge is a shorter version that covers only Phase 1 (colon cleanse) and Phase 2 (liver detox) — the first 7 days of the full program. It's perfect for people who want a quick reset without the extended nutrition phase.
The 7D includes: Liver-D (Liver Support + Liver Mix), 1 bag of Colon-D, and ProEnzi+. If you want the complete transformation including guided nutrition, the 21D Challenge is the better choice.
